Heather House, 16, has been reported missing.
This is the second time since November the teenager has walked away from family and friends.
Her father, Tommy House, said she left for the bathroom at a youth function Sunday and didn't return.
Friends grew anxious and called her father at his house at Malouf Trailer Park around 6 p.m..
She hadn't given any indication that she was troubled, her father said. "She was just being friendly as always."
Heather has blond hair and blue eyes. She stands about 5 feet 4 inches and weighs 160-165 pounds.
She was last seen wearing light brown khakis and dark blue T-shirt with "National Disaster" printed across the front. She was also wearing a pair of pink boat shoes.
This is the sixth time the 10th-grader has turned up missing. Her fathers said she has been running away since she was 14.
Jimmy Tindall, Leflore County undersheriff, said his office is treating Heather's case as a runaway and not an abduction.
Whenever the police bring her back, she won't give any reason why she left, House said.
In November, Heather walked off from her house. She was gone for about a week until Carroll County deputies picked her up in Vaiden.
Her previous absences have ranged in length from two days to a week and a half.
House said Heather has friends in Grenada and Vaiden. He's called them to find out if his daughter is with them, but they won't cooperate. "She thinks I'm not going to find her, but I will," he said.
